Pain and bladder dysfunction in an animal model of multiple sclerosis
نویسندگان
چکیده
منابع مشابه
MAKING AN EXPERIMENTAL ANIMAL MODEL FOR MULTIPLE SCLEROSIS
To understand the mechanism of Multiple Sclerosis (MS), an autoimmune demyelinating disease, the researchers developed an experimental animal model for MS, which is called EAE (Experimental Allergic Encephalomyelitis). There are several methods for inducing this animal model. In this research the active EAE, which is developed by injecting bovine myelin antigens into genetically susceptibl...
متن کاملBladder Dysfunction in Multiple Sclerosis
Disturbances of micturition are important in multiple sclerosis, not only because of their high incidence, the amount of discomfort and embarrassment they cause, and their contribution to the mortality of the disease, but because control of the excretory functions is the most important single factor which determines the patient's admission to hospital. Under satisfactory home conditions many pa...
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Background: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are auto immune demyelinating disorders. Both MS and NMO patients suffer from urinary dysfunction. Objectives: Investigation of frequency and severity of urinary symptoms in two groups of MS and NMO patients. Materials & Methods: 56 MS patients and 20 NMO patients were enrolled in this cross sectional study conducted in Isfah...
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Pain is a widespread and debilitating symptom of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system. Although central neuroinflammation and demyelination have been implicated in MS-related pain, the contribution of peripheral and central mechanisms during different phases of the disease remains unclear. In this study, we used the animal model exp...
متن کاملMS14 Down-regulates Lipocalin2 Expression in Spinal Cord Tissue in an Animal Model of Multiple Sclerosis in female C57BL/6
Background: Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis, which is a demyelinating and an inflammatory disease of central nervous system. Recent studies have established that some molecules such as Lipocaline2 (LCN2), which expresses during inflammatory conditions, play an important role in EAE pathogenesis and might involve in its treatment process. ...
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ژورنال
عنوان ژورنال: Porto Biomedical Journal
سال: 2017
ISSN: 2444-8664
DOI: 10.1016/j.pbj.2017.07.071